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Translational Animal Models in Drug Discovery and Development free ebook download

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Medicine

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Author(s):	Xinkang Wang

Date:	2024	Format:	pdf	Language:	English	ISBN/ASIN:	1608055914
Pages:	287	OCR:		Quality:		ISBN13:
Uploader:	alex21s	Upload Date:	10/13/2023 8:38:13 AM

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Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology. This book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.
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	Title	Link	Password	Size (MB)	Thank to	Inform Admin
3206177	Book	https://nitroflare.com/view/8CDD8AC78D4B...		0.00	alex21s

Tags: Animal Development Discovery Drug Models Translational

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Translational Animal Models in Drug Discovery and Development free ebook download

Category: Medicine

Description: Click to see full description

Category:
Medicine