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Sample Size Determination in Clinical Trials with Multiple Endpoints free ebook download

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Mathematics

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Author(s):	Takashi Sozu, Tomoyuki Sugimoto, Toshimitsu Hamasaki

Date:	2015	Format:	PDF	Language:	English	ISBN/ASIN:	3319220047
Pages:	1	OCR:		Quality:		ISBN13:
Uploader:	eternal	Upload Date:	6/24/2020 12:51:09 PM

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This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area.
The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed  if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also briey examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespecied non-ordering of endpoints.

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	Title	Link	Password	Size (MB)	Thank to	Inform Admin
2809050	Book	https://tezfiles.com/file/7dbddff5d8804...		3.80	eternal

Tags: Clinical Determination Endpoints Multiple Sample Size Trials

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Sample Size Determination in Clinical Trials with Multiple Endpoints free ebook download

Category: Mathematics

Description: Click to see full description

Category:
Mathematics