Development of Selective DNA-Interacting Ligands: Understanding the Function of Non-canonical DNA Structures free ebook download.

Home : Book details

Development of Selective DNA-Interacting Ligands: Understanding the Function of Non-canonical DNA Structures free ebook download

Category:
Chemistry

Views: 269
Likes: 131

Catalogue

Author(s):	Sefan Asamitsu

Date:	2020	Format:	EPUB	Language:	English	ISBN/ASIN:	9811577153
Pages:	1	OCR:		Quality:		ISBN13:
Uploader:	eternal	Upload Date:	9/17/2020 5:37:54 PM

To download click on link in the Links Table below

Description: Click to see full description

This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases.
Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity.

This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (hairpin form) or guanine-rich sequences (G-quadruplex form), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.
i will be very grateful when you support me and buy Or Renew Your Premium from my 
i appreciate your support Too much as it will help me to post more and more
Without You And Your Support We Cant Continue
Thanks For Buying Premium From My Links For Support

Links Table

	Title	Link	Password	Size (MB)	Thank to	Inform Admin
2868970	Book	https://tezfiles.com/file/3fd2f2879c6e9...		33.00	eternal

Tags: Development Function Ligands Non-canonical Selective Structures Understanding

Title	Link	Password	Size	Reason

Those who downloaded this book also downloaded the following books:

Comments

New comment: