Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology) free ebook download.

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Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology) free ebook download

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Biology

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Author(s):	Zhengyin Yan

Date:	2021	Format:	7z	Language:	English	ISBN/ASIN:	1071615416
Pages:	390	OCR:		Quality:		ISBN13:
Uploader:	maveriks	Upload Date:	7/16/2021 3:23:11 AM

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This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading.

Authoritative and practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.

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Tags: Cytochrome Methods Pharmacology Protocols Toxicology Vitro

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