Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy (Recent Advances in Alzheimer Research) free ebook download.

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Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy (Recent Advances in Alzheimer Research) free ebook download

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Medicine

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Author(s):	Ahmad Salehi

Date:	2024	Format:	pdf	Language:	English	ISBN/ASIN:	1681081393
Pages:	320	OCR:		Quality:		ISBN13:
Uploader:	stirkout	Upload Date:	10/9/2023 2:09:15 AM

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Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological hallmarks of Alzheimer's disease. Unfortunately, no extant treatments have proven beneficial for cognitive dysfunction for either Down syndrome or Alzheimers disease. An incomplete understanding of the common pathogenic mechanisms that link these two disorders has limited researchers progress to this end. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a novel attempt to fill this void, by summarizing the work of world-renowned scientists in the field of Alzheimers disease and Down syndrome, and thus providing an unprecedented opportunity to attract attention to Down syndrome as a tool for understanding the common molecular mechanisms that underlie Alzheimers disease and to develop new therapies for similar neurodegenerative disorders of the brain. The book covers the fundamental pathophysiology and molecular mechanisms behind the incidence of Alzheimers disease in Down syndrome affected individuals as well other key topics such as diagnosis and management, in vivo brain imaging studies, and progressive neurodegeneration of the monoaminergic system. The book concludes with a review of recent clinical trials of drugs designed to mitigate cognitive dysfunction in aging adults with Down syndrome and establishes a scientific warrant for the increased testing of candidate pharmacotherapies. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a useful reference for clinicians involved in treating Down syndrome patients as well as for neuroscience researchers seeking to understand the influence of a specific case of aneuploidy on Alzhemiers disease incidence and its progression at the molecular level.
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Tags: Alzheimer between Common Disease Down Mechanisms Pathogenic Steps Syndrome toward

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