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Organelle and Molecular Targeting
We have surpassed the Omics era and we are truly in the Age of Molecular Therapeutics. The fast paced development of SARS-CoV-2 vaccines such as the mRNA vaccines encoding the viral spike protein, demonstrated the need and capability of molecular therapy and nanotechnology based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enables the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. Read more