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Muscle Biopsy
With this book, 'Muscle Biopsy', I published my first book as an editor on diagnosticissues of muscle biopsies - the work which I have cherished for the last 25 years. Theuse and importance of doing and interpreting a muscle biopsy has come a long wayafter the first biopsy was performed by Duchenne to diagnose a myopathic condition.Starting as a relatively less attractive field, myology, particularly myopathology, hasprogressed into one of the most coveted subjects by neurologists, pathologists andbasic scientists. With advances in enzyme histochemistry, molecular pathology andgene analysis, the importance of a muscle biopsy in the diagnosis of primary andsecondary neuromuscular disorders is increasing.The diagnostic algorithm on a muscle biopsy begins with a systematic and thoroughanalysis of histochemical and enzyme histochemical stains. The first two chapters ofthe book deal with these basics of muscle biopsy. The next set of two chapters dealswith basic research techniques of cultures of myotubes and membrane transport.These chapters give an in-depth review of basic techniques seldom covered in anyother book on muscle biopsy and will be of great help to basic scientists.Mitochondrial disease pathology and pathogenesis has made tremendous progressover the last few years and has given answers to many unexplained neuromuscularand systemic ailments. Mitochondria have also established a role in pathogenesis ofdiabetes and obesity. Keeping this in mind, we have included three chapters whichdeal with different aspects of mitochondrial diseases.I am greatly thankful to all the authors of this book for their contributions and hopethe readers benefit from the material.