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Description of  Leptin and Leptin Antagonists

Th e discovery of leptin, the obese (ob) gene product which is not expressed as a functional protein in ob/ob mice, focused the scientifi c community’s attention on its role as an anorexic hormone involved in the negative regulation of food intake. Almost 14 years aft er this breakthrough discovery and over 14,000 leptin-related publications later, leptin is now known to participate in a wide range of biological functions that include, in addition to its early envisaged function as an adipostat, glucose metabolism, glucocorticoid synthesis.