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Description of  'Acute Leukemia: The Scientist's Perspective and Challenge' ed. by Mariastefania Antica

This book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease. The first section discusses the classification of acute leukemia, taking into account diagnoses dependent on techniques that are essential, and thankfully readily available, in the laboratory. The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies. The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients. Contents Preface Part 1 Introduction 1 Classification of Acute Leukemia 2 Diagnosis of Acute Leukemia in Under-Resourced Laboratories Part 2 Molecular Mechanisms and Markers 3 The PI3K/PKB Signaling Module in Normal and Malignant Hematopoiesis 4 Lymphocyte Commitment and Ikaros Transcription Factors 5 Epigenetics and Targeted Therapy in Acute Leukemia 6 Molecular Markers for Risk Stratification in Adult Acute Myeloid Leukemia with Normal Cytogenetics 7 Trafficking of Acute Leukemia Cells - Chemokine Receptor Pathways that Modulate Leukemia Cell Dissemination 8 Biochemistry of the Mixed Lineage Leukemia 1 (MLL1) Protein and Targeted Therapies for Associated Leukemia Part 3 Pediatric Acute Leukemia 9 Diagnostics of Molecular Markers in Childhood Acute Leukaemia Using Biochips 10 Pediatric Acute Myeloid Leukemia 11 Pediatric Natural Killer Cell Malignancy 12 Leukemogenesis in Down Syndrome Part 4 Treatment and Future Prospects 13 Cord Blood Transplantation in Adults with Acute Leukemia 14 Acute Lymphoblastic Leukemia in Adolescents and Young Adults 15 Evidence-Based Guided Interventions in Acute Leukemia 16 Hematologic Malignancies in Pregnancy 17 Chemotherapy Toxicity in Patients with Acute Leukemia 18 Vitamin D and Acute Myeloid Leukemia with TOC BookMarkLinks