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Description of  Acid Peptic Diseases and related disorders Pocket: E-chart included

Acid Peptic Diseases and related disorders Pocket E-chart included. Acid peptic diseases are a large group of gastrointestinal disorders that is mainly characterized by excessive gastric acid secretion and diminished gastrointestinal defense. The most common acid peptic diseases encountered by gastroenterologists are gastroesophageal reflux disease and peptic ulcer disease. The two major causes of peptic ulcer disease are long-term use of non-steroidal anti-inflammatory drugs and infection with the bacterium Helicobacter pylori. Zollinger-Ellison syndrome is another acid peptic disease in which the development of a neuroendocrine pancreatic or duodenal tumor results in hypersecretion of gastric acid. Although all of these diseases have overlapping symptoms and pathogenic factors, clinical presentation and outcomes can vary considerably. In recent decades, our understanding of the etiologies underlying acid peptic diseases has evolved, as have diagnosis and management strategies. In particular, proton pumps inhibitors have dramatically changed how acid peptic diseases are treated. They have emerged as the most potent drug class that suppress gastric acid secretion, prevent gastrointestinal complications and promote healing if they occur, without tachyphylaxis. In this work, the pathogenesis underlying specific acid peptic diseases and related complications or disorders are described, and our current knowledge of the environmental, pathophysiological, and genetic factors that may contribute to disease etiologies is summarized. Importantly, key points and recommendations from internationally recognized diagnosis and management guidelines for these acid peptic diseases are stated. New advances in disease management are also discussed. Table of Contents Foreword Abbreviations and Acronyms Chapter 1: Gastroesophageal Reflux Disease and Its Complications Overview GERD pathogenesis Lifestyle and environmental factors Pathophysiology Reflux esophagitis Genetic and epigenetics of GERD Genetic factors Epigenetic factors Epidemiology Symptoms Diagnosis Management Pharmacotherapy PPIs Lifestyle and diet modifications Surgery and endoscopic surgery Follow-up Prognosis Special concerns Pediatric GERD Epidemiology Symptoms Diagnosis Management Lifestyle modifications Pharmacotherapy Surgery Follow-up Prognosis for pediatric GERD patients Special concerns for pediatric GERD patients Complications associated with GERD Dyspepsia Symptoms Diagnosis Management Prognosis Erosive esophagitis Epidemiology Symptoms Diagnosis Management Follow-up Prognosis Peptic strictures Epidemiology Symptoms Diagnosis Management Dilation Pharmacotherapy Surgery Prognosis Barretts esophagus Epidemiology Symptoms Diagnosis Management Surgery Endoscopic therapy Surveillance Prognosis Esophageal adenocarcinoma New advances in the management of GERD Conclusion Chapter 2: Hiatal Hernia Overview Pathogenesis of sliding hiatal hernia Anatomical features Pathophysiology Genetics Other factors Epidemiology Symptoms Diagnosis Management Lifestyle modifications Pharmacotherapy Surgery Prognosis Special concerns New advances in the management of hiatal hernia Conclusion Chapter 3: Gastrointestinal Complications Related to Chronic NSAID Use Overview NSAIDs: mechanism of action Pathogenesis Pathophysiology NSAIDs and small intestine injury Risk factors Genetics Epidemiology Symptoms Diagnosis Management Prevention strategies PPIs Misoprostol H2RAs COX-2 inhibitors PUD Epidemiology Symptoms Diagnosis Management Pharmacotherapy for NSAID-induced PUD PPIs H2RAs Surgery Prognosis Special concerns Gastrointestinal bleeding or hemorrhage Epidemiology Symptoms Diagnosis Management Endoscopic therapy Pharmacotherapy Antibiotics PPIs Follow-up Prognosis Special concerns Conclusion Chapter 4: Helicobacter Pylori Infection Overview H. pylori pathogenesi Read more